Vadim Gladyshev - Harvard Medical School, Division of Genetics, Department of Medicine

Systems Aging and Rejuvenation

    Date:  03/17/2022 (Thu)

    Time:  3:30pm- 5:00pm

    Location:  This seminar will be held remotely via Zoom. (Please sign in to see the link.)

    Organizer:  Laura Satterfield

Meeting Schedule: (Not currently open for scheduling. Please contact the seminar organizer listed above.)

    All meetings will be held in the same location as the seminar unless otherwise noted.

    3:30pm - Seminar Presentation (3:30pm to 5:00pm)

    Additional Comments:  What is aging? When does it begin? How to control lifespan? Can we rejuvenate organisms in addition to slowing down the aging process? There is no consensus, but recent developments in the field allow to begin answering these questions. In particular, DNA methylation of defined sets of CpG dinucleotides emerged as a critical and precise biomarker of the aging process. Multi-variate machine learning models, known as epigenetic clocks, can exploit quantitative changes in the methylome to predict the age of bulk tissue with remarkable accuracy. The first epigenetic aging clock that works at the level of single cells has also been recently developed. Together with advances in genomics and intervention strategies, these tools support accurate quantification and manipulation of the aging process. Additional topics to be covered in the talk will include development and application of molecular signatures of longevity and research on different types of rejuvenation.